Testagen (Bioregulator)
$60.00
What is Testagen (Bioregulator)?
Testagen is a synthetic tetrapeptide (Lys-Glu-Asp-Gly) from the Khavinson class of bioregulatory peptides developed at the Saint Petersburg Institute of Bioregulation and Gerontology. It is designed to target testicular tissue through proposed peptide-DNA interactions modulating gene expression in Leydig and Sertoli cells. The Khavinson model proposes that Testagen influences transcription of genes involved in testicular function, including steroidogenic enzyme expression and spermatogenic cell differentiation markers. Testagen has been investigated in Russian biogerontology research examining age-related changes in male reproductive function and testicular tissue homeostasis. It is part of the organ-specific bioregulator family alongside compounds targeting cardiac, hepatic, pulmonary, and other tissues.
Mechanism of Action
Testagen has been investigated for its proposed interactions with gene regulatory regions in testicular cells. The Khavinson model proposes that the Lys-Glu-Asp-Gly sequence penetrates cell membranes and interacts with DNA in promoter regions of testis-expressed genes. Researchers have observed that Testagen treatment in testicular cell culture models was associated with changes in expression of steroidogenic enzymes (including StAR and CYP11A1) and Sertoli cell differentiation markers. Studies suggest that the peptide may influence the balance between proliferative and differentiated states in testicular tissue. These effects are attributed to direct peptide-DNA interactions and epigenetic modulation rather than conventional gonadotropin receptor signaling.
Published Research
Testicular Biology
Khavinson et al. (2006) investigated testicular-targeted bioregulatory peptides and observed changes in gene expression related to steroidogenic function and spermatogenesis markers in cell culture models [1].
Bioregulatory Peptide Framework
Khavinson VK (2002) described the comprehensive model for tissue-specific bioregulatory peptides including those targeting reproductive tissues [2].
Aging and Reproductive Function
Khavinson et al. (2012) reviewed bioregulatory peptide effects on age-related endocrine changes, including male reproductive tissue biology [3].
Product Specifications
| Product | Testagen (Bioregulator) Lyophilized Powder |
|---|---|
| Available Sizes | 20mg |
| Purity | ≥99% (HPLC verified) |
| Sequence | Lys-Glu-Asp-Gly |
| Molecular Formula | C₁₄H₂₄N₄O₈ |
| Molecular Weight | 392.36 g/mol |
| Appearance | White lyophilized powder in glass vial |
| Storage | Store at -20°C or 2-8°C desiccated. Protect from moisture. |
| Testing | Third-party tested — Certificate of Analysis available |
Frequently Asked Questions
Testagen is a synthetic tetrapeptide (Lys-Glu-Asp-Gly) from the Khavinson bioregulatory peptide family, designed to target testicular tissue.
Testagen targets testicular tissue, including Leydig and Sertoli cells, in the Khavinson bioregulatory model.
Store at -20°C or 2-8°C desiccated, protected from moisture.
No, Testagen is not a hormone. It is a short bioregulatory peptide proposed to modulate gene expression in testicular cells through peptide-DNA interactions.
Yes, Testagen belongs to the Khavinson class of bioregulatory peptides from the Saint Petersburg Institute.
References
- Khavinson V, et al. Short peptides and reproductive biology. Bull Exp Biol Med. 2006;142(1):108-110.
- Khavinson VK. Peptides and Ageing. Neuroendocrinol Lett. 2002;23 Suppl 3:11-144. PMID: 12374906
- Khavinson V, et al. Peptide regulation of aging. Adv Gerontol. 2012;25(3):407-416.
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