Selank
$33.00
What is Selank?
Selank is a synthetic heptapeptide consisting of the naturally occurring immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg) extended with a Pro-Gly-Pro C-terminal sequence. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank is approved in Russia as an anxiolytic and nootropic medication, typically administered intranasally. The tuftsin portion provides immunomodulatory properties (tuftsin is a natural product of IgG cleavage that activates monocytes and macrophages), while the Pro-Gly-Pro extension confers neurotropic activity and enhanced stability. Selank has been studied in both clinical and preclinical settings for its dual anxiolytic and immunomodulatory profile, which is unique among anxiolytic agents. Unlike benzodiazepines, Selank does not produce sedation, cognitive impairment, or dependence in studied populations.
Mechanism of Action
Selank has been investigated for its modulation of multiple neurotransmitter and immune signaling systems. Researchers observed that Selank allosterically enhances GABA-A receptor function, increasing GABAergic inhibitory neurotransmission in limbic regions involved in anxiety processing. Studies suggest that this GABA-A modulation occurs at a site distinct from the benzodiazepine binding site, which may explain the absence of sedation and dependence. Selank also modulates serotonergic neurotransmission, with researchers observing effects on 5-HT metabolism and receptor expression in the hippocampus and prefrontal cortex. The peptide increases BDNF expression in brain regions relevant to anxiety and cognition. Through its tuftsin component, Selank activates phagocytic immune cells and modulates cytokine profiles, providing immunomodulatory effects alongside its CNS activity. In clinical studies, Selank administration was associated with changes in anxiety scores without significant sedation or cognitive impairment.
Published Research
Anxiolytic Profile
Seredenin et al. (1998) characterized Selank’s anxiolytic activity in preclinical models, demonstrating effects comparable to benzodiazepines without sedation or cognitive impairment [1].
Immunomodulatory Activity
Uchakina et al. (2008) investigated Selank’s effects on immune function and observed modulation of cytokine profiles and immune cell activation, establishing the dual anxiolytic/immunomodulatory profile [2].
Neurotransmitter Modulation
Narkevich et al. (2008) investigated Selank’s effects on monoamine neurotransmitter metabolism in brain regions. Researchers observed changes in serotonin and dopamine turnover in the hippocampus and striatum [3].
Product Specifications
| Product | Selank Lyophilized Powder |
|---|---|
| Available Sizes | 10mg |
| Purity | ≥99% (HPLC verified) |
| CAS Number | 129954-34-3 |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| Molecular Formula | C₃₃H₅₇N₁₁O₉ |
| Molecular Weight | 751.87 g/mol |
| Appearance | White lyophilized powder in glass vial |
| Storage | Store lyophilized at -20°C. Reconstituted solution at 2-8°C, use within 14 days. |
| Testing | Third-party tested — Certificate of Analysis available |
Frequently Asked Questions
Selank is a synthetic heptapeptide combining tuftsin (Thr-Lys-Pro-Arg) with a Pro-Gly-Pro extension. It is approved in Russia as an anxiolytic and nootropic medication.
The CAS registry number for Selank is 129954-34-3.
In clinical studies, Selank was not associated with significant sedation or cognitive impairment, distinguishing it from benzodiazepine anxiolytics.
Store lyophilized Selank at -20°C. Once reconstituted, store at 2-8°C and use within 14 days.
Tuftsin (Thr-Lys-Pro-Arg) is a natural tetrapeptide derived from IgG that activates monocytes and macrophages. It forms the core of the Selank sequence.
N-Acetyl Selank Amidate has protective N-acetyl and C-amide caps that improve metabolic stability. Selank is the unmodified parent peptide.
References
- Seredenin SB, et al. Anxiolytic action of the synthetic peptide selank. Bull Exp Biol Med. 1998;125(5):456-458.
- Uchakina ON, et al. Immunomodulatory effects of selank in patients with anxiety-asthenic disorders. Bull Exp Biol Med. 2008;145(2):230-232.
- Narkevich VB, et al. Effects of selank on monoamine metabolism in brain regions. Bull Exp Biol Med. 2008;146(12):726-728.
Customer Reviews
Five stars earned. Quality speaks for itself.
Reordering because the first batch was flawless.
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Professional packaging, fast delivery, great product.
Product arrived fast and in perfect condition.
Happy with the product. Packaging could be improved slightly.
