NA Epitalon
$45.00
What is NA Epitalon?
N-Acetyl Epitalon (NA Epitalon) is a stabilized derivative of Epitalon (Ala-Glu-Asp-Gly), the Khavinson bioregulatory tetrapeptide studied for its interactions with telomerase activity and pineal gland function. The N-acetyl capping at the N-terminus and C-terminal amidation protect the peptide from exopeptidase degradation — aminopeptidases at the N-terminus and carboxypeptidases at the C-terminus — extending its biological half-life compared to unmodified Epitalon. These modifications are standard peptide chemistry strategies that preserve the core pharmacophore while improving pharmacokinetic properties. NA Epitalon retains the same Ala-Glu-Asp-Gly sequence and is expected to engage the same proposed peptide-DNA interaction sites as the parent compound, but with enhanced resistance to enzymatic degradation during circulation and cellular uptake.
Mechanism of Action
NA Epitalon has been investigated under the same mechanistic framework as standard Epitalon. The parent compound is proposed to interact with gene regulatory regions, including the hTERT (telomerase reverse transcriptase) promoter, modulating telomerase expression in somatic cells. Researchers have also studied Epitalon’s effects on pineal gland melatonin synthesis through modulation of AANAT enzyme expression. The N-acetyl and amide modifications in NA Epitalon protect against exopeptidase cleavage, potentially increasing the fraction of intact peptide that reaches target cells compared to unmodified Epitalon. Studies on the parent compound suggest effects on telomere maintenance, melatonin synthesis enzymes, and markers of cellular senescence (p16, p21, SA-β-galactosidase). The enhanced stability of NA Epitalon may allow it to maintain bioactive concentrations for a longer duration, though comparative pharmacokinetic studies between the two forms are limited.
Published Research
Epitalon and Telomerase
Khavinson et al. (2003) investigated Epitalon (the parent compound of NA Epitalon) in senescent fibroblast cultures and observed reactivation of telomerase activity and extended replicative lifespan, providing the mechanistic basis for the stabilized derivative [1].
Pineal Function
Korkushko et al. (2007) investigated Epitalon in elderly subjects and observed changes in melatonin rhythms and circadian parameters, establishing the pineal component of the peptide’s activity profile [2].
N-Acetyl Amide Peptide Stabilization
Powell et al. (1993) reviewed the use of N-terminal acetylation and C-terminal amidation as strategies for improving peptide stability against exopeptidases, providing the chemical rationale for the NA Epitalon modification [3].
Product Specifications
| Product | NA Epitalon Lyophilized Powder |
|---|---|
| Available Sizes | 10mg |
| Purity | ≥99% (HPLC verified) |
| Sequence | Ac-Ala-Glu-Asp-Gly-NH₂ |
| Molecular Formula | C₁₆H₂₅N₅O₁₀ |
| Molecular Weight | 447.40 g/mol |
| Appearance | White lyophilized powder in glass vial |
| Storage | Store lyophilized at -20°C. Reconstituted solution at 2-8°C, use within 21 days. |
| Testing | Third-party tested — Certificate of Analysis available |
Frequently Asked Questions
NA Epitalon is a stabilized derivative of Epitalon with N-acetyl and C-terminal amide modifications that protect against enzymatic degradation while preserving the bioregulatory peptide's activity.
NA Epitalon has N-acetyl and C-terminal amide caps that protect against exopeptidase degradation. The core Ala-Glu-Asp-Gly sequence and proposed mechanism are the same.
Store lyophilized NA Epitalon at -20°C. Once reconstituted, store at 2-8°C and use within 21 days.
N-terminal acetylation and C-terminal amidation are standard peptide chemistry modifications that preserve the core pharmacophore while improving resistance to enzymatic degradation.
NA Epitalon is studied in the same contexts as Epitalon: telomerase biology, pineal function, melatonin pathways, and biogerontology research.
References
- Khavinson VK, et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592. PMID: 12937682
- Korkushko OV, et al. Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people. Adv Gerontol. 2007;20(1):74-85.
- Powell MF, et al. Peptide stability in drug development. Pharm Res. 1993;10(9):1268-1273. PMID: 8234159
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