N-Acetyl Selank Amidate
$33.00
What is N-Acetyl Selank Amidate?
N-Acetyl Selank Amidate is a stabilized derivative of Selank, itself a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg) with a Pro-Gly-Pro extension. The N-acetyl and C-terminal amide modifications enhance the peptide’s resistance to aminopeptidase and carboxypeptidase degradation, extending its biological half-life compared to unmodified Selank. Selank was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and is approved in Russia as an anxiolytic and nootropic medication. The base Selank sequence combines the immunomodulatory tuftsin fragment with a Pro-Gly-Pro extension that confers additional neurotropic properties. N-Acetyl Selank Amidate represents an effort to improve the pharmacokinetic profile of this peptide while preserving its anxiolytic and immunomodulatory activities observed in preclinical and clinical research.
Mechanism of Action
N-Acetyl Selank Amidate has been investigated for its modulation of GABAergic neurotransmission and neurotrophic factor expression. Researchers observed that Selank and its analogs interact with GABA-A receptor allosteric sites, enhancing GABAergic inhibitory signaling without the sedation or dependence associated with benzodiazepine GABA-A modulators. Studies suggest that Selank peptides also modulate serotonergic neurotransmission, with effects on 5-HT metabolism and receptor expression in limbic brain regions. In preclinical models, researchers observed that Selank administration was associated with increased expression of BDNF and its receptor TrkB in hippocampal and cortical regions, providing a neurotrophic mechanism distinct from its direct effects on GABA signaling. The N-acetyl and amide modifications protect the peptide from exopeptidase degradation, extending its functional half-life. The tuftsin-derived portion of the sequence also confers immunomodulatory activity through effects on monocyte/macrophage function and cytokine profiles.
Published Research
Anxiolytic Activity
Seredenin et al. (1998) investigated Selank in anxiety models and observed anxiolytic-like effects comparable to benzodiazepines but without the associated sedation or cognitive impairment, establishing the pharmacological basis for its clinical approval in Russia [1].
GABA and Serotonin Modulation
Kasian et al. (2019) investigated Selank’s effects on GABA-A receptor function and serotonergic signaling. Researchers observed allosteric enhancement of GABAergic transmission and modulation of 5-HT turnover in anxiety-relevant brain regions [2].
Neurotrophic Effects
Agapova et al. (2007) demonstrated that Selank administration was associated with increased BDNF mRNA expression in hippocampal regions, providing evidence for neurotrophic mechanisms beyond direct neurotransmitter modulation [3].
Product Specifications
| Product | N-Acetyl Selank Amidate Lyophilized Powder |
|---|---|
| Purity | ≥99% (HPLC verified) |
| Sequence | Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH₂ |
| Molecular Formula | C₃₅H₅₇N₁₁O₁₀ |
| Molecular Weight | 795.90 g/mol |
| Appearance | White lyophilized powder in glass vial |
| Storage | Store lyophilized at -20°C. Reconstituted solution at 2-8°C, use within 14 days. |
| Testing | Third-party tested — Certificate of Analysis available |
Frequently Asked Questions
It is a stabilized version of Selank, a synthetic heptapeptide derived from tuftsin. The N-acetyl and amide modifications improve resistance to enzymatic degradation.
The N-acetyl cap and C-terminal amidation protect against exopeptidase degradation, extending the peptide's biological half-life while preserving the same pharmacological activity.
Store lyophilized at -20°C. Once reconstituted, store at 2-8°C and use within 14 days.
Tuftsin (Thr-Lys-Pro-Arg) is a naturally occurring tetrapeptide derived from immunoglobulin G that modulates monocyte and macrophage function. Selank extends this sequence with Pro-Gly-Pro.
Selank is approved in Russia as an anxiolytic and nootropic medication. N-Acetyl Selank Amidate is a modified version studied in the research context.
N-Acetyl Selank Amidate is studied in the context of anxiolytic signaling, GABA modulation, BDNF expression, serotonergic pathways, and immunomodulation.
References
- Seredenin SB, et al. Anxiolytic action of the synthetic peptide selank. Bull Exp Biol Med. 1998;125(5):456-458.
- Kasian A, et al. Selank peptide affects GABA-A receptor function. Neurochem J. 2019;13:182-189.
- Agapova EA, et al. Selank increases BDNF expression in rat hippocampus. Bull Exp Biol Med. 2007;143(5):583-586.
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