IPA/TESA Blend
$90.00
What is IPA/TESA Blend?
The IPA/TESA Blend combines ipamorelin, a selective GH secretagogue receptor (GHSR) agonist, with tesamorelin, a stabilized GHRH analog, in a single research formulation. Like the Ipamorelin + CJC-1295 blend, this combination exploits the well-characterized synergy between GHRH and GHSR signaling pathways at the pituitary. Tesamorelin (trans-3-hexenoic acid modified GHRH 1-44) is an FDA-approved GHRH analog with enhanced stability compared to native GHRH. When paired with ipamorelin, it provides GHRH receptor activation that synergizes with ipamorelin’s GHSR activation for amplified GH release. The key difference from the IPA/CJC blend is the GHRH component — tesamorelin is a full-length 44-amino acid GHRH analog compared to the 29-amino acid CJC-1295 No DAC, and it carries FDA approval for clinical use in HIV-associated lipodystrophy.
Mechanism of Action
The IPA/TESA Blend has been investigated for its dual activation of GHRH receptor and GHSR signaling in pituitary somatotrophs. Tesamorelin activates the GHRH receptor through Gs-coupled adenylyl cyclase signaling, increasing cAMP and activating PKA, which primes GH secretory vesicles. Ipamorelin activates GHS-R1a through Gq-coupled phospholipase C, increasing IP3 and intracellular calcium, which triggers vesicle fusion and exocytosis. Researchers observed that this convergent signaling produces synergistic GH release. Tesamorelin’s trans-3-hexenoic acid modification at the N-terminus protects against DPP-IV cleavage, extending its effective half-life compared to native GHRH. Studies suggest that the full 44-amino acid sequence of tesamorelin may engage additional receptor contacts compared to truncated GHRH analogs. Ipamorelin’s selectivity ensures GH release without cortisol, prolactin, or significant appetite stimulation.
Published Research
Tesamorelin Clinical Data
Falutz et al. (2007) investigated tesamorelin in a randomized clinical trial and demonstrated its ability to stimulate endogenous GH secretion and modulate visceral adipose tissue parameters, establishing the clinical profile of this blend component [1].
GHRH-GHSR Synergy
Bowers et al. (1990) demonstrated the synergistic interaction between GHRH and GH secretagogues at the pituitary level, providing the mechanistic basis for combining tesamorelin with ipamorelin [2].
Ipamorelin Selectivity
Raun et al. (1998) characterized ipamorelin’s selectivity profile, demonstrating GH release without significant cortisol or prolactin co-secretion [3].
Product Specifications
| Product | IPA/TESA Blend Lyophilized Powder |
|---|---|
| Available Sizes | IPA 5mg / TESA 10mg (15mg) |
| Purity | ≥99% (HPLC verified) |
| Sequence | Ipamorelin: Aib-His-D-2-Nal-D-Phe-Lys-NH₂ | Tesamorelin: trans-3-hexenoic acid-modified GHRH(1-44) |
| Appearance | White lyophilized powder in glass vial |
| Storage | Store lyophilized at -20°C. Reconstituted solution at 2-8°C, use within 14 days. |
| Testing | Third-party tested — Certificate of Analysis available |
Frequently Asked Questions
The IPA/TESA Blend combines ipamorelin (GHSR agonist) with tesamorelin (GHRH analog) for synergistic GH secretagogue research.
The GHRH component differs u2014 tesamorelin is a full 44-amino acid GHRH analog with FDA approval, while CJC-1295 No DAC is a 29-amino acid modified GHRH fragment.
Store lyophilized at -20°C. Once reconstituted, store at 2-8°C and use within 14 days.
Tesamorelin is a stabilized GHRH(1-44) analog with a trans-3-hexenoic acid modification. It is FDA-approved for clinical use and stimulates endogenous GH secretion.
Yes, both Ipamorelin and Tesamorelin are available as individual products.
References
- Falutz J, et al. Metabolic effects of a growth hormone-releasing factor in patients with HIV. N Engl J Med. 2007;357(23):2359-2370. PMID: 18057338
- Bowers CY, et al. On the actions of the growth hormone-releasing hexapeptide, GHRP. Endocrinology. 1990;128(4):2027-2035.
- Raun K, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-561. PMID: 9849822
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