Gonadorelin Acetate
$40.00
What is Gonadorelin Acetate?
Gonadorelin acetate is the synthetic acetate salt form of gonadotropin-releasing hormone (GnRH), a naturally occurring decapeptide produced by the hypothalamus that controls the reproductive endocrine axis. GnRH is released in a pulsatile manner from hypothalamic neurons and acts on gonadotroph cells in the anterior pituitary to stimulate secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The native GnRH sequence (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂) was first characterized by Schally and Guillemin in the 1970s, work that earned them the Nobel Prize in Physiology or Medicine. Gonadorelin is identical to the endogenous hormone and is used clinically as a diagnostic agent for evaluating pituitary gonadotroph function. The pulsatile nature of GnRH release is essential for its physiological activity — continuous exposure leads to receptor downregulation.
Mechanism of Action
Gonadorelin has been investigated for its activation of the GnRH receptor (GnRHR), a Gq-coupled GPCR expressed on anterior pituitary gonadotroph cells. Researchers observed that binding of gonadorelin to GnRHR activates phospholipase C, generating IP3 and DAG, leading to calcium mobilization and PKC activation. This signaling cascade stimulates exocytosis of LH and FSH from secretory granules and promotes transcription of gonadotropin subunit genes (LHβ, FSHβ, and common α-subunit). Studies demonstrate that pulsatile GnRH administration maintains gonadotroph responsiveness, while continuous administration leads to GnRHR desensitization and downregulation — a phenomenon exploited therapeutically by GnRH agonists. The frequency and amplitude of GnRH pulses differentially regulate LH versus FSH secretion: high-frequency pulses favor LH, while low-frequency pulses favor FSH. Researchers have utilized gonadorelin as a diagnostic provocative test to assess pituitary gonadotroph reserve and distinguish hypothalamic from pituitary causes of hypogonadism.
Published Research
GnRH Discovery
Schally et al. (1971) isolated and characterized the structure of GnRH (then called LHRH) from porcine hypothalamic extracts. This Nobel Prize-winning work established the decapeptide sequence and its role as the master regulator of the reproductive hormone axis [1].
Pulsatile Signaling
Belchetz et al. (1978) demonstrated that pulsatile GnRH administration sustains gonadotropin secretion while continuous infusion causes desensitization in primate models. This landmark study established the importance of pulsatile delivery in GnRH physiology [2].
Diagnostic Applications
Snyder PJ (1985) reviewed the clinical use of gonadorelin as a provocative test for pituitary gonadotroph function, establishing protocols for differentiating hypothalamic from pituitary causes of reproductive hormone deficiency [3].
Product Specifications
| Product | Gonadorelin Acetate Lyophilized Powder |
|---|---|
| Available Sizes | 2mg |
| Purity | ≥99% (HPLC verified) |
| CAS Number | 33515-09-2 |
| Sequence | pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂ |
| Molecular Formula | C₅₅H₇₅N₁₇O₁₃ |
| Molecular Weight | 1,182.29 g/mol |
| Appearance | White lyophilized powder in glass vial |
| Storage | Store lyophilized at -20°C. Reconstituted solution at 2-8°C, use within 14 days. |
| Testing | Third-party tested — Certificate of Analysis available |
Frequently Asked Questions
Gonadorelin is synthetic GnRH (gonadotropin-releasing hormone), a naturally occurring hypothalamic decapeptide that stimulates LH and FSH secretion from the pituitary.
The CAS registry number for gonadorelin is 33515-09-2.
Pulsatile GnRH maintains pituitary responsiveness and gonadotropin secretion. Continuous GnRH exposure causes receptor downregulation and suppression of LH/FSH release.
Store lyophilized Gonadorelin at -20°C. Once reconstituted, store at 2-8°C and use within 14 days.
Yes, gonadorelin has the identical amino acid sequence as endogenous human GnRH. The acetate refers to the salt form used for stability.
The hypothalamic-pituitary-gonadal (HPG) axis is the hormonal cascade where hypothalamic GnRH stimulates pituitary LH/FSH, which in turn stimulates gonadal hormone production.
References
- Schally AV, et al. Isolation and properties of porcine thyrotropin-releasing factor and luteinizing hormone-releasing factor. J Biol Chem. 1971;246(23):7230-7236. PMID: 4942342
- Belchetz PE, et al. Hypophysial responses to continuous and intermittent delivery of hypothalamic gonadotropin-releasing hormone. Science. 1978;202(4368):631-633. PMID: 100883
- Snyder PJ. The gonadotropin-releasing hormone provocative test in man. Endocr Rev. 1985;6(4):655-668.
Customer Reviews
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Impressed with the quality. Packaging was professional.
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